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Evivo™ with MCT Oil Now Accessible as Single Use Vial for Hospital Use

DAVIS, Calif., Dec. 11, 2017 /PRNewswire/ — Evolve BioSystems, Inc. immediately introduced a first-to-market, single-use liquid type of Evivo (activated B. infantis EVC001, ActiBif®). Evivo with MCT Oil, the primary and solely probiotic clinically confirmed to work with breast milk to revive a child’s intestine microbiome to its pure state, is now accessible as single use administration for infants in a hospital setting. Analysis signifies that B. infantis could also be each restorative and protecting within the toddler intestine. Administering Evivo with breast milk is clinically confirmed to permit B. infantis to thrive and dominate the toddler intestine microbiome whereas additionally lowering relative populations of doubtless dangerous micro organism, akin to E. coli, clostridia, Staphylococcus (Staph), and Streptococcus (Strep).

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A wholesome intestine microbiome at start paves the way in which for lifelong well being. Trendy medical practices akin to C-sections, antibiotic use and components feeding together with environmental elements within the hospital can impression the event of the toddler microbiome. Analysis has proven that administration of probiotics to infants within the hospital is secure and efficient, and will cut back the incidence of many severe, and generally devastating situations. Probiotic administration has additionally been linked to shorter time to full feeds and will cut back incidence of sepsis.

“Security and constant prime quality are essential within the NICU surroundings,” mentioned Thomas Younger, MD, neonatologist and former NICU director and Mom’s Milk Financial institution medical director at WakeMed in Raleigh, North Carolina. “Evivo with MCT Oil, as a single-use liquid product, will likely be preferable to probiotics in powder type or multiuse packaging. This formulation permits for administration to time period infants within the NICU and is a necessary step towards correctly designed scientific trials in neonates going ahead.”

On this formulation, Evivo’s useful micro organism are combined with medium chain triglyceride oil (MCT oil), offering a secure and streamlined method to ship the probiotic to infants in a hospital setting. Evivo helps defend the child’s intestine microbiome via quite a lot of actions derived from its means to eat human milk oligosaccharides (HMOs). The useful micro organism in Evivo are capable of make the most of the HMOs in breast milk in a singular and superior method in comparison with different intestine micro organism, and convert HMOs into vitamins that nourish each the toddler and the intestine microbiome. The micro organism in Evivo have been proven to be anti-inflammatory, to lower intestinal permeability, and enhance the manufacturing of lactate and acetate, which might suppress the expansion of doubtless dangerous micro organism. Moreover, Evivo given day by day to breastfed infants was proven to lead to considerably fewer unfastened and watery stools per day, with out a rise in incidence of jaundice or different antagonistic occasions. 

“Rising the degrees of useful micro organism whereas reducing ranges of doubtless dangerous micro organism might play a big function in mitigating among the commonest dangers these susceptible infants face within the NICU,” mentioned David Kyle, PhD, chief scientific officer of Evolve BioSystems. “Evivo reprograms the toddler intestine microbiome and helps infants make the most of the complete dietary worth of human milk, which helps the last word purpose of wholesome weight acquire and getting them dwelling with their households.”

Evolve BioSystems’ landmark scientific trial, not too long ago printed within the American Society for Microbiology journal mSphere, confirmed that offering dietary B. infantis EVC001 resulted in fast, substantial, and protracted reworking of the intestine microbiome in breastfed infants. This steady colonization of B. infantis EVC001 led to vital discount within the abundance of doubtless dangerous micro organism. As well as, this improved intestine profile continued for greater than 30 days after dietary B. infantis was discontinued, so long as infants continued to eat breast milk.

About Evolve BioSystems
Evolve BioSystems, Inc. is a privately-held microbiome firm devoted to growing the following technology of merchandise to determine, restore, and preserve a wholesome intestine microbiome. Evolve is a spin-out from the Meals for Well being Institute (FFHI) on the College of California, Davis and builds on greater than a decade of analysis into understanding the distinctive partnership of the toddler intestine microbiome and breast milk parts. Having led to the event and industrial launch of merchandise to resolve new child intestine dysbiosis, together with Evivo for infants and GlycoGuard® for nursing foals, Evolve’s discovery platform is now being utilized to fixing intestine dysbiosis all through the human life cycle in addition to different animal species. Along with the landmark proof-of-concept IMPRINT trial, Evolve is enterprise additional scientific research to construct out its suite of microbiome-based options.

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